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Sprycel (Dasatinib)

  Sprycel (Dasatinib)

Sprycel (Dasatinib)

Sprycel (Dasatinib) is a prescription treatment used for certain types of leukemia, including chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) with the Philadelphia chromosome. It works by blocking specific proteins (BCR-ABL and SRC kinases) that promote cancer cell growth, helping to slow or stop the spread of abnormal cells in the body.

Why Choose Sprycel (Dasatinib)?

  • Targets and blocks cancer-causing proteins to control disease progression.
  • Proven efficacy in patients resistant or intolerant to prior therapies such as imatinib.
  • Available in convenient oral tablet form for at-home treatment.
  • Helps achieve and maintain remission in the chronic phase of CML.
  • Provides a long-term treatment option with a manageable safety profile.

How to Use Sprycel (Dasatinib)?

  • Take Sprycel exactly as prescribed by your healthcare provider, do not alter or skip doses.
  • Swallow the tablet whole; do not crush, cut, or chew.
  • Take it at the same time each day, with or without food.
  • Avoid grapefruit or grapefruit juice, as it may affect how the medicine works.
  • Store tablets at room temperature, away from moisture and direct sunlight.
  • If a dose is missed, take it as soon as possible unless it’s almost time for your next dose, never double up.

Important Safety Information about Sprycel

  • Regular blood tests are necessary to monitor blood cell counts and liver function.
  • Inform your healthcare provider about all medications and supplements you are taking to avoid interactions.
  • Not recommended during pregnancy or breastfeeding, discuss safe options with your doctor.
  • Use caution if you have a history of heart problems, bleeding disorders, or liver disease.

Fact Table

 
Facts Details
Generic Name Dasatinib
Brand Name Sprycel
Drug Class Tyrosine Kinase Inhibitor (TKI)
Dosage Forms Oral Tablets
Route of Administration Oral
Mechanism of Action Dasatinib inhibits multiple tyrosine kinases, including BCR-ABL, SRC family kinases, c-KIT, ephrin receptors, and PDGFβ receptors. This blocks the signaling pathways that promote cancer cell proliferation and survival.
Indications / Uses - Treatment of adults and children with Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic, accelerated, or blast phase. - Treatment of Ph+ acute lymphoblastic leukemia (ALL) with resistance or intolerance to prior therapy.
Administration Instructions - Take once daily, with or without food. - Swallow tablets whole; do not crush, cut, or chew. - Avoid use of grapefruit products (may increase drug levels).
Onset of Action Varies by patient; therapeutic response may be observed within weeks to months of continuous therapy.
Storage Conditions Store at 25°C (77°F); excursions permitted between 15–30°C (59–86°F). Keep in the original container and protect from moisture.
Contraindications Hypersensitivity to dasatinib or any component of the formulation.
Precautions / Warnings - Myelosuppression: May cause neutropenia, thrombocytopenia, or anemia. - Fluid Retention: Risk of pleural or pericardial effusion. - QT Prolongation: Use with caution in patients with cardiac disorders. - Hepatotoxicity: Monitor liver function tests. - Avoid strong CYP3A4 inhibitors or inducers (e.g., ketoconazole, rifampin).
Common Side Effects - Fatigue, headache, dizziness - Nausea, vomiting, diarrhea - Rash, skin irritation - Edema (especially around the eyes or ankles) - Myelosuppression (low blood cell counts)
Drug Interactions - Avoid CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin). - Avoid CYP3A4 inducers (e.g., rifampin, phenytoin). - Proton pump inhibitors (PPIs) and H2 blockers can reduce absorption. - Use caution with anticoagulants or antiplatelet drugs.
Prescription Status Prescription-only

Common Side Effects

Like all medications, Sprycel (Dasatinib) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
  • Headache or fatigue
  • Nausea, vomiting, or diarrhea
  • Skin rash or mild itching
  • Low blood cell counts (anemia, neutropenia, thrombocytopenia)
  • Muscle or joint pain
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Sprycel (Dasatinib)?

You can order Sprycel (Dasatinib) using these methods on our website:
  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills
Visit our How to order page.
Dr. Conor Sheehy, PharmD, BCPS

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.

Please note that due to government rules and regulations, orders may not exceed 3 months in supply.
Please call 1-800-258-0477 or email us if you have any questions or concerns.