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Lodalis (Colesevelam Hydrochloride)

  Lodalis (Colesevelam Hydrochloride)

Lodalis (Colesevelam Hydrochloride)

Lodalis (Colesevelam Hydrochloride) is used to lower high cholesterol levels and improve blood sugar control in adults with type 2 diabetes. It works by binding bile acids in the intestine, preventing their reabsorption, which helps remove cholesterol from the body. When combined with a healthy diet and regular exercise, Lodalis supports better heart and metabolic health.

Why Choose Lodalis (Colesevelam Hydrochloride)?

  • Helps lower LDL (bad) cholesterol levels
  • Improves blood sugar control in adults with type 2 diabetes
  • Can be used alongside statins or other cholesterol-lowering therapies
  • Non-systemic, works in the gut, not the bloodstream
  • Suitable for long-term management when prescribed by a healthcare provider

How to Use Lodalis (Colesevelam Hydrochloride)?

  • Take Lodalis exactly as prescribed by your doctor.
  • Swallow tablets whole with a full glass of water; do not crush or chew.
  • Take with meals and plenty of fluids to aid absorption.
  • If taking other medications, space them at least 4 hours before or after Lodalis to avoid interference.
  • Maintain a balanced diet and regular physical activity for the best results.

Important Safety Information about Lodalis

  • Inform your doctor if you have a history of bowel obstruction, swallowing disorders, or chronic constipation.
  • Tell your healthcare provider about all medications and supplements you use, as Lodalis can affect the absorption of certain drugs (e.g., levothyroxine, phenytoin, oral contraceptives).
  • Regularly monitor your cholesterol and blood sugar levels during treatment.
  • Do not use Lodalis if you have known hypersensitivity to Colesevelam or any of its ingredients.

Fact Table

 
Facts Details
Brand Name Lodalis
Generic Name Colesevelam Hydrochloride
Drug Class Bile Acid Sequestrant
Purpose To lower LDL cholesterol and improve glycemic control in adults with type 2 diabetes
Dosage Form Film-coated oral tablet
Common Package Sizes Bottles or blister packs containing 180 or 300 tablets (varies by supplier)
Route of Administration Oral
How It Works Binds bile acids in the intestine to prevent their reabsorption. This prompts the liver to use more cholesterol to make new bile acids, reducing LDL (“bad”) cholesterol levels. It also helps improve blood glucose control by mechanisms that are not fully understood.
Indications / Uses - Primary hyperlipidemia (high cholesterol) - Type 2 diabetes mellitus (as adjunct to diet and exercise)
Administration Tips - Take with food and plenty of fluids - Swallow tablets whole (do not crush or chew) - Separate other medications by at least 4 hours before or after taking Lodalis
Onset of Action Gradual; may take several weeks to see cholesterol-lowering effects
Contraindications - Bowel obstruction - History of severe gastrointestinal disorders - Hypersensitivity to Colesevelam or any ingredients in the formulation
Cautions / Warnings - Use with caution in patients with swallowing difficulties or gastrointestinal motility disorders - May increase triglyceride levels; monitor periodically - May reduce absorption of fat-soluble vitamins (A, D, E, K) with long-term use
Storage Conditions Store at room temperature (15°C–30°C), away from moisture and heat. Keep out of reach of children.
Common Side Effects - Constipation - Indigestion or abdominal discomfort - Nausea - Gas or bloating - Muscle or joint pain
Overdose Symptoms May cause severe gastrointestinal discomfort or constipation; seek medical attention immediately.

Common Side Effects

Like all medications, Lodalis (Colesevelam Hydrochloride) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
  • Constipation
  • Indigestion or stomach pain
  • Nausea
  • Gas or bloating
  • Mild muscle aches
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Lodalis (Colesevelam Hydrochloride)?

You can order Lodalis (Colesevelam Hydrochloride) using these methods on our website:
  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills
Visit our How to order page.
Dr. Conor Sheehy, PharmD, BCPS

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.

Please note that due to government rules and regulations, orders may not exceed 3 months in supply.
Please call 1-800-258-0477 or email us if you have any questions or concerns.