Epclusa (Sofosbuvir/ Velpatasvir)

Epclusa is a medication approved for the treatment of all six major forms of the hepatitis C virus (HCV). Comprising two powerful antiviral agents, Sofosbuvir and Velpatasvir, Epclusa offers a simplified treatment regimen for adults, providing a path to cure for those with and without cirrhosis.

Why Choose Epclusa (Sofosbuvir/ Velpatasvir)?

Broad Spectrum: Effective across all genotypes (1-6) of the hepatitis C virus.
High Cure Rates: Demonstrates a cure rate of over 95% in clinical trials.
One-Pill Regimen: Convenient daily dosing with just one tablet.
No Need for Ribavirin: Most patients don’t require the addition of Ribavirin, reducing potential side effects.

How to Use Epclusa (Sofosbuvir/ Velpatasvir)?

Take one tablet daily with or without food.
Treatment duration generally spans 12 weeks, as prescribed by a healthcare professional.
Consistent daily intake at the same time each day is recommended to maintain the drug’s effectiveness.

Important Safety Information about Epclusa

Patients who are allergic to sofosbuvir, velpatasvir, or any of the inactive ingredients in Epclusa® should not take this medication.
Epclusa® may interact with other medications and supplements, which can potentially lead to significant interactions that may reduce the effectiveness of Epclusa® or the other drugs, or worsen side effects.
There is limited data on the use of Epclusa® in pregnant women. It is advisable to consult a healthcare provider regarding the risks and benefits of using Epclusa® during pregnancy and breastfeeding.

Fact Table

Facts	Details
Brand Name	Epclusa®
Generic Name	Sofosbuvir / Velpatasvir
Indications	Treatment of chronic hepatitis C virus (HCV) in adults for all genotypes (1-6)
Dosage Form	Oral tablet
Strength	Sofosbuvir 400 mg / Velpatasvir 100 mg
Recommended Dosage	One tablet is taken orally once daily with or without food
Treatment Duration	Typically 12 weeks
Efficacy Rate	Over 95% cure rate in clinical trials across all genotypes
Common Side Effects	Headache, fatigue, nausea
Contraindications	Patients with hypersensitivity to the active ingredients or any component of the formulation
Key Warnings	Screen for HBV before starting treatment; risk of serious symptomatic bradycardia with amiodarone coadministration
Drug Interactions	Anticonvulsants, antimycobacterial, herbal supplements like St. John’s Wort, certain HIV antiretrovirals
Use in Specific Populations	Caution in pregnant women and nursing mothers; assess risks and benefits; monitor severe renal and liver impairments
Mechanism of Action	Sofosbuvir inhibits NS5B polymerase, and Velpatasvir inhibits NS5A, both essential for viral replication
Marketing Status	Prescription drug

Common Side Effects

Like all medications, Epclusa (Sofosbuvir/ Velpatasvir) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

Headache
Fatigue
Nausea

If you experience any of these side effects or others, make sure to discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Epclusa (Sofosbuvir/ Velpatasvir)?

You can order Epclusa (Sofosbuvir/ Velpatasvir) using these methods on our website:

Order Online
Order by Phone
Order by Fax
Order your refills

Visit our How to order page.